Since you try to bring scientific rigor into the discussion, could you point me to some evidence that the epiphenomal effects of the named condition are clearly merely caused by a temporary increase in receptor densities?
Having taken several neuroscience classes, I think that claim is a gross oversimplification and an overly reductionist take on the incredibly complex topic at hand.
> So tell me again how this is beneficial?
I can't answer that question as I have made no statement about any purported benefits or lack thereof.
> could you point me to some evidence that the epiphenomal effects of the named condition are clearly merely caused by a temporary increase in receptor densities?
When someone takes prozac and tries to stop, they have withdrawal effects. Prozac increases serotonin which increases receptor density.
1. The results of this study are about long-term treatment, not a single dose.
2. The study makes absolutely zero claims about the epiphenomenal effects of receptor site increases/decreases, as far as I can see. That is your interpretation (with no evidence.) Sure, people describe withdrawal effects after quitting a drug that made them feel good, and there might be a correlation with decreasing receptor sites and those withdrawal symptoms, but you have not established any causal links, the main point I asked you about.
3. In the original comment you associated the generally positive effects that the OOP described as a consequence of decreasing serotonin receptor sites. Yet then you make a claim based on this study that decreasing receptor sites cause negative withdrawal effects. It very much seems like those two claims contradict themselves? Honestly a bit confused here what you're trying to say.
> I have been studying neurobiology for 20 years.
Well that's impressive. May I ask what your h-index is?
> 1. The results of this study are about long-term treatment, not a single dose.
DMT acts on the HTR2A and HTR2C receptors. When you activate HTR2C receptors at high levels the nerves respond by changing the number HTR2C receptors. This is called having an "effect of receptor density".
You can read about it in this study: (I know what you are going to say, that this proves one cannot get habituated to DMT But that is wrong adn you will need to read the second study to understand why.
Because drug efficacy changes with receptor density and cellular microenvironment, we also examined the properties of DMT in native preparations using a behavioral and biochemical approach."
One difference was evident in that the 5-HT2C, but not the 5-HT2A, receptor showed a profound desensitization to DMT over time. This difference is interesting in light of the recent report that the hallucinogenic activity of DMT does not tolerate in humans and suggests the 5-HT2C receptor plays a less prominent role in the action of DMT.
Furthermore, abnormal receptor density ratios are strongly associated with positive and negative symptom severity, which are typically assessed using the Scale for the Assessment of Negative Symptoms
In addition, Hurlemann et al. (2007) proposed that 5-HT2A receptor density was also decreased in the At-Risk Mental State patient subgroup, regardless of conversion to psychosis [4]. The progressive decline in subcortical 5-HT2A receptor density could provide an indicator of conversion to schizophrenia.
> That is your interpretation (with no evidence.)
That is what is called a hypothesis. Do you ever have an original insight or do you just walk around nixing creative thought because no one ever thought of it before?
I mean you focus only on the study and you cannot see the connection because you so myopic.
> Well that's impressive. May I ask what your h-index is?
It is people like you who keep science in the dark ages.
I cured my schizo-affective Bipolar disorder without medication. What have you done?
Having taken several neuroscience classes, I think that claim is a gross oversimplification and an overly reductionist take on the incredibly complex topic at hand.
> So tell me again how this is beneficial?
I can't answer that question as I have made no statement about any purported benefits or lack thereof.