Nothing inherently, it doesn't have the “full of spammers” stigma of .xyz and so forth, though some seem to think it inherently means non-profit/non-commercial (sort of true, it was defined as for organisations not fitting in other tlds where .com was one of those and intended for commercial use) and think .com therefor looks more serious.

Also: if you take the .org and the .com is already in use, be ready to have the name taken off you if they get successful, or for some of your users to mistakenly go to the wrong place. To avoid one of those things happening later if the .com is available now you could buy both, but then the availability of the .com becomes the deciding factor again not the .org and you are paying for two domains.