This is in the context of symmetric keys, so I'm guessing "huge keys" is a reference to the fact that "448-bit crypto" is a giant red flag because it screams "we're using blowfish".
See I just write 1/5th of a recommendation and leave it open-ended so Colin or 'pbsd can make it look like I was smart to begin with. Yeah... Blowfish... that's what I meant... :)
Well, in the more general case "huge symmetric keys" is a flag for "doesn't understand crypto", but 448-bit blowfish keys are the most common place I see this happening.
What is your opinion on Threefish then? Is there something fundamentally wrong with bigger keys/blocks, or is it just that known big key/block schemes are not useful?