You won't know in advance who is going to rob you, in this case it was the FBI but for this attack it could be anyone, even a reasonably organized group of 13 year olds could probably pull this off. For example the situation could be the same but DPR is a tech CEO working in a coffeeshop in Asia, and someone has just ran off with a copy of his email and financials. He chases them out of the door, gets hit in the face with a bike chain, and wakes up in the hospital, not even knowing if they were just aggressive petty thieves, or if he was targeted and someone knows all this plans.
I think that "lock and wipe" might be too much though, and locking only would be more practical, wouldn't constitute destruction of evidence (as far as they know), wouldn't punish mistakes so much. Right now, off the shelf, a computer will lock up on screensaver, or sleep/poweroff. For a high paranoia user, you could add headphone unplug, power cord in/out, any usb in/out, even monitor the mic for certain codewords to trigger the lock. And if it happens it isn't such a big deal, just re-authenticate.
So now it's the locking mechanism that's gotta be made plausibly deniable. The beauty of it being done in software via (say) an HID interrupt is that the software itself is protected by the act of locking the computer.
I think that "lock and wipe" might be too much though, and locking only would be more practical, wouldn't constitute destruction of evidence (as far as they know), wouldn't punish mistakes so much. Right now, off the shelf, a computer will lock up on screensaver, or sleep/poweroff. For a high paranoia user, you could add headphone unplug, power cord in/out, any usb in/out, even monitor the mic for certain codewords to trigger the lock. And if it happens it isn't such a big deal, just re-authenticate.