The article could have done a better job making clear that RNA topology has been extensively studied using computational linguistics, and much of the work by Chomsky applied directly.
Note: "The general problem of predicting lowest free energy structures with pseudoknots has been shown to be NP-complete."
http://en.wikipedia.org/wiki/Pseudoknot
Note: "The general problem of predicting lowest free energy structures with pseudoknots has been shown to be NP-complete." http://en.wikipedia.org/wiki/Pseudoknot