"Q meets Edith Head" is how she was planned and sketched out, but I'm fond of these little details that make a character unique.
True story: I once was on Maui, and stopped inside a curio shop. The owner of the shop, a little Japanese woman, came out from the back and smiled at me -- and I'll be God-damned if she didn't look exactly like Edna -- perfectly sculptured hair, glasses, and all. I found myself actively looking for a secret lab behind all the blown-glass trinkets. It was only after this incident that I found out Edna was conceptualized as part Japanese; and today I wonder if someone at Pixar didn't visit the same shop, meet the same woman, and incorporate her into Edna's design.
I have a friend at the Savannah College of Art and Design that was a student under her who mentioned this. Apparently its quite the accurate portrayal and her students don't receive an A unless its something she would put in her own collection.
[1] http://en.m.wikipedia.org/wiki/Edith_Head