So far I've seen "you can't print this out!" (who cares?) and "some of the transitions could be smoother!"
This one is my favorite:
"This isn't a one-page form. It's not going to fit on my desk. I'm going to pass on this candidate."
Seriously people? You think this guy doesn't have a hard copy of his resume? Your goal is to hire a talented candidate. This exercise demonstrates talent, and was created for exposure. Not optimization of communication in the form of a one-page CV that will end up decomposing on some hiring manager's desk that doesn't have the decency to reply to candidates he or she will not be hiring.
Well the other positive about this resume other than it being fantastic is that you know for certain you don't want to work anywhere that passes on you because of your beautifully designed, creative resume.