Having used Adblock (currently Adblock Edge) and Ghostery/Disconnect for so long, I haven't seen ads in ages. It's actually a bit jarring when I use a computer that doesn't have ad blocking enabled... everything suddenly gets so cluttered.
Yeah, I've visited websites for years that I felt were very well designed in regards to being open and having a nice amount of whitespace. Seeing the same site on someone else's computer is a bit heartbreaking.