Lately I've been using my phone to do a cycle of 15/5 minutes sitting/standing, with standing time also being a break from the computer. It's worked really well. The break time is not really an interruption; 5 minutes is enough for most small chores, and if I don't have any of those, I can use it for mindfulness practice. Plus chopping it up gives me better estimates about time usage and how much I can get out of any given work day - after a certain point it becomes clear that I'm spending most of each cycle on distractions, so I'll start adjusting my plan to match reality.

I could probably use Pomodoro or any similar cycle and also get good results, I just happened to try this first.