Very cool - I didn't know about this. However, this still presupposes you have a local Python/Django/Mezzanine installation. Simple for a Django web developer, probably not too bad for a non-Django web developer - but it's a bit much to expect a non Developer to set up Python, Django, and Mezzanine on their local system.
On the other hand, I see a way to make this simple for a non developer. Set up a virtual machine with everything all set up. Then all the end user would have to do is download VMware or virtualbox. Then download the VM image with Ubuntu/Django/Mezzanine/Fabric. And then you'd be approaching the same level of simplicity of getting started with self-hosted Wordpress.
On the other hand, I see a way to make this simple for a non developer. Set up a virtual machine with everything all set up. Then all the end user would have to do is download VMware or virtualbox. Then download the VM image with Ubuntu/Django/Mezzanine/Fabric. And then you'd be approaching the same level of simplicity of getting started with self-hosted Wordpress.