I love the hell out of zombie movies but unless you're really going to do something unique it may end up being too cliche. I second the advice on just using another variation on the post-apocalyptic setting.
I'm just investigating the idea at the moment, I don't have my heart set on the zombie genre.
I guess I'm really trying to feel my way through various settings that could be technologically doable with a small-scale team. This is just one of the proposals, but it seems a good fit for the moment.