Yes, it does. You may know what there would be realignment, but you don't know where or how, and may not possess the professional knowledge and resources required to profit from it directly. The known part is general, the unknown part is specific and time-dependent.
Someone else already said: yes all companies go to zero on a timeline that includes the heat death of the universe. Your claim is about as clever as that.
No, that would only work after getting really high. You know, when somebody asks "why this thing is such and such?" and you answer "why things are at all? Maybe it's all just our imagination, dude! Maybe nothing makes sense and we are living in a simulation! Dude, just feel you mind expanding!"
But if we lay off the bong for a bit and think soberly, then no, knowing that certain economic process is not sustainable and will eventually collapse, but not being able to profit from it is not the same as saying every bubble would pop at the heat death of the universe, billions years for now. It's so not the same that the very comparison should be immediately perceived as absurd.
