No, they’re not. Of the 20 largest airports in the US, all but one of them have homes and offices surrounding them. The one that doesn’t is Denver, that’s mostly only because Denver’s airport is relatively new and the development hasn’t reached it yet.
I'm sure this is an airport most of the people on this site are familiar with but just in case you aren't, it's on reclaimed land in the San Francisco bay.
It is 400m from the threshold of 19L/1R to the nearest residential neighborhood at SFO. LGA, which is an incredibly urban airport has the exact same distance from the end of its closest runway to the nearest residential area.