I understand that trying to take supplements to slow aging is a crap shoot. That said I take Taurine in the form of eating dark chicken meat, legs and thighs. I also take NAD+ with resveratrol as publicized by David Sinclair at Harvard.
I believe that the very best thing to do to maintain health and perhaps have higher quality of life, later in life, is to meditate, forgive other people and yourself, and generally balance spirituality, good sleep, good food, and walk outside a few times a day.
EDIT: left off two big things. As we age we need vitamin D supplements and I personally also believe in loading up on Omega 3 by eating walnuts, chia seeds, and salmon.
Don’t forget some type of strength training. There’s plenty of research that it reduces all cause mortality. Likely by pushing back the time you become frail.
This might get turned on its head in a couple years. Some new research just came out on combining incretin based therapies (ie semaglutide) with myostatin blockers (in this case trevogrumab and garetosmab) and the monkey lost a crap load of fat while also putting on muscle mass. It's a hell of a time to be a monkey, hopefully it translates into a hell of a time to be a human in a few years. Also, I would like some samples of whatever substance the guys naming these drugs are consuming. Whatever it is, they are wasting it on naming drugs when they should be using it to write science fiction.
Absolutely. I saw this with aging loved ones. The most “durable” ones fared better as they aged and had health issues.
As you age, each acute medical event has a real impact and recovery is slow and limited. You have to be at an high baseline to crawl back up.
My dad had a stroke that really affected him badly, but he recovered a lot and worked hard. It was all set back by a cold and a uti that resulted in a hospitalization. That basically did him in. Everything you can do to make sure that you can stand up and get around as long as possible means that you’ll be able to live a longer fulfilling life.
I should, but I don't. I do hike four hours a week and swim for a half hour every day very early in the morning. Thanks for the reminder, you are 100% correct. I am in my mid 70s, so I think I only need resistance training about twice a week.
Here's an exercise anyone can do almost everyday that will increase bone density. I do it in the shower or wherever there's a solid safe tile floor:
Start with both knees and hips bent (like a football linebacker just before the snap), legs apart and arms bent at the side to maintain balance. Set one foot slightly ahead of the other. Now, using primarily the heels of your feet, jump up slightly(preferably only a few inches) and slam both heels back down, while switching which foot is forward. [Don't jump so much that you straighten your legs; instead keep knees bent at all times]. You're hopping in place and striking your heels on the ground, with the right foot forward first and then with the left foot forward, back and forth. Make sure the heel hits the tile and bears the brunt of the force (rather than the toes). Do 20 of these hops each time you're in the shower.
Slamming the heel of the foot into the floor vibrates the large bones of the legs. These vibrations will strengthen (all of) your bone over time.
No anaerobic training? You’ll really want that bone density and general mobility down the line, and it also helps greatly aligning the others (pushes you to sleep, eat ealthier, helps with stress etc)
I've been doing a similar routine + intermittent fasting (Late breakfast/early dinner) + NMN and metformin. Probably isn't doing anything useful.
Re vitamin D: I supplement with that as well, but for a tangential reason: Avoiding sun exposure (esp mid-day) without sunblock avoids photoaging and reduces skin cancer risk. But this leaves you at a Vitamin D deficit, hence the supplement.
I have a tub of taurine, but haven't been taking it; seemed like the evidence was thin, and this article supports that conclusion.
Yes, intermittent fasting seems to have good effects. I used to restrict eating to the period 11am to about 5pm, and I felt better. Now all I do is to avoid eating any food within three hours of going to bed. I don't know how reliable my Apple Watch really is, but my deep sleep ratings are much better when I stop eating after a light early dinner, and this makes some sense: if you are actively digesting food your heart rate is probably increased and generally your body can settle down. As you know, digesting food is a major activity.
Science has shown that the best quality sleep is achieved when core temperature drops about 3 degrees, and this is almost impossible when one has eaten a meal within an hour or two of going to bed.
Or if you live in a hot country. But that makes me suspicious of this finding - it should mean that everyone (without AC) in hot countries sleeps badly. I doubt that to be true though.
Wouldn't surprise me. This is a tough nut to crack because it is likely true, but photo aging and skin cancer are unquestionably true and negative effects of UV exposure.
Are you getting enough vitamin k complex? Depending on the D dose you are taking there are some indications that that might be important to avoid arterial calcification (among other things).
https://pmc.ncbi.nlm.nih.gov/articles/PMC5613455/
Will depend on age and the definition of underweight. Intermittent fasting is probably generally beneficial to maintain the health of already healthy humans up to 75 years of age. But at that age exercise and weights (gently) probably more helpful.
As far as I know there is little if any proven benefit to vitamin D supplementation, but a lot of links between high vitamin D and good health markers. Just a reminder that you should try to get some sun exposure as well for natural vitamin D, as that may well be where the health benefits really come from
As an aside when it comes to sun and vitamin D: your body will still produce vitamin D from the sun if you wear sunscreen. You also get all the mental health benefits like serotonin and whatnot with sunscreen.
So, if you're a partial sun plant (white person), you should get sun but you should use sunscreen, and you'll be fine and that will work.
These are all good life practices but you've forgotten one key component of mental aging: many individuals' growing lack of curiosity as they age. Lifelong learning, and generally also contact with others, is very important to keeping the mind sharp as one gets older.
My Dad lived to almost 102 and he was learning new things right up to the end of his life. He was a physics professor and Berkeley but in retirement he got into model trains, organized social activities, and taught himself 3D animation and started writing scripts and got into digital story telling.
So, I agree with you, always learning new things makes life interesting and probably has health benefits.
"It is a major constituent of bile and can be found in the large intestine. It is named after Latin taurus (cognate to Ancient Greek ταῦρος, taûros) meaning bull or ox, as it was first isolated from ox bile in 1827 by German scientists Friedrich Tiedemann and Leopold Gmelin."
I believe that the very best thing to do to maintain health and perhaps have higher quality of life, later in life, is to meditate, forgive other people and yourself, and generally balance spirituality, good sleep, good food, and walk outside a few times a day.
EDIT: left off two big things. As we age we need vitamin D supplements and I personally also believe in loading up on Omega 3 by eating walnuts, chia seeds, and salmon.