A human mind simulating another human mind is a computational system which is powerful enough to do arithmetic acting on itself, so Gödel's incompleteness theorems apply.
What I'm getting at is that you won't achieve anything by simulating a human brain. Which doesn't mean nobody will try, the World's Richest Man seems determined to send humans to Mars, which is equally futile, but just that it is definitely futile and here's why we know that.
