Yesterday afternoon I transitioned from Brave to Firefox. Brave was struggling, admittedly after a system uptime of 69 days, even after killing it brave would regularly struggle and do a whole ton of disc I/O, bringing my system to its knees. Rebooting fixes it, FYI, but it seems weird that "pkill -f brave" doesn't seem to resolve it. Slack also has similar struggles, this is under Ubuntu 22.04.
So far Firefox has been a bit rocky, I don't seem to be able to open Jira tickets. Some might consider that a feature, but my job isn't one of them. That's shaken my faith in Firefox more than a bit.
If you have site-specific issues, if you're up to it it would be great if you could report it via the menu (or Help, on MacOS) -> Report broken site, or via https://webcompat.com.
FWIW my default Firefox profile is chock full of content blockers, so I expect demanding sites to fail on first load. I grant additional permissions manually, when I must.
But I had no (extra) trouble opening Jira tickets a few months ago when working with a partner integration.