If you're looking to move away from Chrome, Firefox + uBlock Origin is still your best bet IMO. Mozilla's committed to keeping the robust ad-blocking capabilities alive despite Google's changes.
Brave is decent too if you want something Chromium-based but more privacy-focused (comes with minor controversies).
Safari works well if you're in the Apple ecosystem.
I actually run a dual-browser setup these days - Firefox for most browsing, and only fire up Brave for those annoying sites that Google has mysteriously "optimized" to run poorly elsewhere. Not ideal but gets the job done!