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Where do you get multiple weeks? From what I can find, harman and norharman both have elimination half-lives shorter than half an hour.

If it was weeks, they would accumulate to very toxic levels in anyone who smokes or has a few cups of coffee a day.




That’s in blood. Both are fat soluble and will get stored in brain fatty tissue where the half-life is multiple weeks.

Your second point is spot on.


Interesting. Do you have a source on this? I can't seem to find any detailed data on this. Only some suggestions that since they're lipophilic, and are found in higher concentrations in brain tissue, they might accumulate there. I can't find any research analyzing whether they do accumulate in brain tissue and how long they stay there.




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