I am having so many issues with my vision. I don't have a very high prescription(+1.5 on left and +1.25 on my right) but I consulted 3 eye doctors and optometrists last year. I still don't think my prescription is correct as I get headaches and my eyes get tired after few hours. I don't know if there is any better solution around.
You need to specify your working distance. I use reading glasses with my laptop and occupational glasses with desktop LCDs. If I accidentally pick up the wrong glasses I notice the less-clear vision.
High display brightness tends to hurt more with glasses than without.