If your startup is selling to US government, sure, but otherwise I don't think there is much unreliability in selling SaaS, courses, or whatever gadget to US residents?
I agree there's no need for personal insults here, it's not nice to see especially on HN where one comes to expect better, but I think you can understand the place of exasperation it was coming from. The American government has become vociferously hostile in a very pronounced way recently and for the people on the receiving end of the hostility it feels like an attack in itself to hear "what's the problem, why are you worried?"
The opinions on the government differ, the losing side appears to blame all and everything to the government. Although tariffs, if any, will definitely have an impact, but it doesn't seem like any startup will be blocked from selling to the US, and I don't see why will one not want to sell to the US if there are buyers there.
We will get Greenland one way or another. That's a horrid statement if you are Danish (and worse if you live on that island). Realistically it's a horrid statement, anyways.
From a UK perspective (and I'm not a CEO or anything) it looks pretty volatile over there. Tariffs, radical changes to government funding, widespread corporate overhauls... . Predictability is surely desirable when considering dependencies.
If you depend on the US for defense, and the USA says that the victim should just surrender, there's a risk the same might happen to you. It's quite black and white in this case.