There are a lot of issues with this study, but I'll start with the obvious one: They exposed those stem cells to a concentration of 15μM luteolin. That's grossly non-physiological. There's no way that you're ever going to see a 15µm plasma concentration following luteolin supplementation, at any reasonable dose.
What's more: "Luteolin exhibits limited blood-brain barrier permeability (−0.907) and CNS permeability (−2.251), indicating poor penetration into the brain."
So if 15µm concentrations are unattainable in plasma, the brain would be exposed to much less still.
In animal experiments, as noted in your link, luteolin appears beneficial. There could be a dose-response-curve thing, where reasonable (physiological) amounts are neuroprotective, whereas exposing cells to very high concentrations directly is damaging.
What's more: "Luteolin exhibits limited blood-brain barrier permeability (−0.907) and CNS permeability (−2.251), indicating poor penetration into the brain."
> https://www.sciencedirect.com/science/article/pii/S222541102...
So if 15µm concentrations are unattainable in plasma, the brain would be exposed to much less still.
In animal experiments, as noted in your link, luteolin appears beneficial. There could be a dose-response-curve thing, where reasonable (physiological) amounts are neuroprotective, whereas exposing cells to very high concentrations directly is damaging.