Here is the official FAQ: https://github.com/uBlockOrigin/uBOL-home/wiki/Frequently-as...
For some context, I currently have 393,405 network filters + 385,476 cosmetic filters.
"The current limit imposed by the various implementations is a guaranteed 30K. It is possible for an extension to use more rules, but anything above the global limit will not be enforced. Currently, the global limit in Chromium is 330K static rules."