Oh, sure. There are lots of things in lots of spirits. Sugars, distillation methods, heart-cut precision can all yield different effects from a spirit, but I can distill a bottle of vodka that's predominately methanols and acetaldehydes from the heads that are perfectly clear, and definitely not better for you than the same spirit from just five minutes later in the distillation.
https://www.eds.clinic/articles/low-histamine-alcohol-histam...