I agree for opioids. And I'm certainly not saying there are 'huge numbers of deaths' linked to ketamine. Maybe specialK is popular where you live, but here long term ketamine habits seem quite rare, based on my totally unscientific impression. I also think ketamine abuse isn't very much studied, at least compared to more popular drugs. What I'm saying is that while a short term stint into ketamine probably isn't a big deal, I expect long term use with higher dosage ('ketamine hole', tolerance and all that) to be more dangerous. Having your blood pressure peak in the 250's can't be that safe when you start aging.