Cold cannot be "made", as it's an absence of something (energy), nor can it "leak" as a result.
I take what you mean is that there will be a refrigeration loop involved, and in that, a refrigerant. Just like all substances, refrigerants can be toxic, sure, but that alone is not what makes a toxin [0]. It's also not a binary thing, and between air conditioning and refrigerators, an appliance like this I don't see why would stand out.
I further haven't got a clue what microplastics having been found to pass the blood brain barrier have to do with this, or how you're able to determine whether that applies to me or not, specifically.
