I think the iCloud services is based on the region of your Apple Account. So you could theoretically use a US region Apple Account and enjoy iCloud services. But that means you won't get UK region apps, except in the app store you can switch to different Apple Accounts as you please, so you can have multiple accounts for different regions (which is what I do).
Btw, as a European citizen, I always buy my devices in the USA. We can complain about the US as much as we want, but Europe is on another level.