Klinefelter syndrome: one to two per 1,000 live birth
Turner syndrome: 1 in 2,000 to 5,000 female births
Triple X syndrome: approximately 1 in 1,000 (female)
Jacob’s syndrome: 1 in 1,000 males
Mosaicism affecting sex determination: 1 in 10,000 to 1 in 50,000
Swyer syndrome: ~1 in 80,000–100,000 births
SRY translocation to X or autosome: ~1 in 25,000–30,000
Androgen Insensitivity Syndrome: 1 in 10,000–50,000
So there are ~0.3% of people who have an unusual sex determination because of genetics. As another poster said that means there are 900,000 people with these conditions in the USA. That's half of the transgender population in the USA.
Yet I agree that does not prove that a significant portion of the transgender population has some genetic variation affecting their sex determination, but definitely it proves that the situation is more complex than many think.
Turner syndrome: 1 in 2,000 to 5,000 female births
Triple X syndrome: approximately 1 in 1,000 (female)
Jacob’s syndrome: 1 in 1,000 males
Mosaicism affecting sex determination: 1 in 10,000 to 1 in 50,000
Swyer syndrome: ~1 in 80,000–100,000 births
SRY translocation to X or autosome: ~1 in 25,000–30,000
Androgen Insensitivity Syndrome: 1 in 10,000–50,000
So there are ~0.3% of people who have an unusual sex determination because of genetics. As another poster said that means there are 900,000 people with these conditions in the USA. That's half of the transgender population in the USA.
Yet I agree that does not prove that a significant portion of the transgender population has some genetic variation affecting their sex determination, but definitely it proves that the situation is more complex than many think.