It's more like statistical mechanics and the foundations of the second law of thermodynamics.

Unless entropy is a damned lie. Which I'm not saying it isn't, but claiming such a thing is a pretty strong claim. Possibly one of the strongest claims you can make in physics (which is why it's associated with cranks).

I'd expect some perpetual motion machines after overturning such a principle.

But I do agree you need to be careful defining the scope of microstates and macro states.