I should point out that we are hiring! Software engineering, data science/ML, and IT positions are available in Salt Lake City, Toronto, New York, and London:

https://job-boards.greenhouse.io/recursionpharmaceuticals

Do you guys have a cooldown period for applications?

Not that I know of! Note that the positions we list are typically in different teams so it's worth reading the descriptions to make sure you're picking whichever one is most appropriate to your experience+interests (and, as a corollary, if you weren't a fit for a previous position, you may be one for one that comes up in the future).

they dont respond to cold apps in my experience, except canned rejection after a few months for some reason

We definitely do (as in, I myself have) hire folks from "cold" inbound applications.

I got a response to a cold application within the last year.

Do you guys have high hopes for video data? Were there early results that showed promise for kinetic data?

Yes, we (and plenty of others) have prior data showing that perturbations (things that you can do to cells, like knocking out genes or putting drug-candidates on them) have different effects at different times, so we are excited to see the potential for time course imaging.

Note that "video" is a little different here than the way we all usually think of it - think "minutes or hours between frames" not "frames per second".