Well, it depends. If those people are willing to accept our differences, then I reciprocate, and we can be friends. I accommodate them, they accommodate me. But if gap is too big to be bridged (they have a completely different personality), or they don't want to reciprocate (they insist on doing things their way because obviously that's normal and better and everything) then I just stop caring, and treat them as necessary evil. Coworker is passionate about ruining a project and manager won't do anything about it? Not my problem, just make sure that my suggestions were written down and then rejected. I'm not paid to do engineering, I'm paid to put up with stupid people and office politics while doing minimal amount of engineering. Aunt feels the need to spread the word of Jesus? Well, looks like next time I won't make it to visit her, and if I absolutely need to because of complex family relationships, I'll just nod and smile while being mentally absent.

At the same time, I refuse to spend my free time with people who challenge my patience. There's a clear distinction between professional/family me, and the leisure time me.