I think people need to appreciate that the number of developers interested in actually helping with free software maintenance is a subset of the number of developers. And when it comes to Python in particular, that subset is proportionally very small. That's just my anecdotal experience of similar projects in both ecosystems.
Python has been around for a long time and there were some attempts at creating a modern package manager for it. If it were feasible to create uv in Python, it would have probably happened by now.
There's a barrier of entry for the army of people who use Python but are not (and often have no interest in being) engineers/developers/programmers.
This is the modern equivalent of building key components in Visual C++ for use by Visual Basic people; it kept the unwashed masses away from things they could break.
I think that this is probably the only way you're ever going to fix the horrific experience of using Python in anger. Which is a good thing, Python's a great little language which is let down by being built on sand.