I would say the analogy fails because it's not about discomfort or weirdness (or taste); left-handed scissors just don't work if you try to use them right-handed. But right-handed scissors don't work if you try to use them left-handed either.
So it's not about taste or preference, left handed people learn how to use right-handed scissors, but they can also use left handed scissors in a way that a right-handed person would struggle to.
All that said, the analogy still works because most people don't understand why it doesn't work.
As a lefty who has used right-handed scissors in many situations all my life, it isn't that simple. I can cut with right-handed scissors. It requires changing the way I use them in a way that is a bit weird and unnatural, but it works.
It's very much about what is comfortable for people.
100% agree that to make them work in the wrong hand you need to use them in a way that feels weird but the original comment was:
> a righthanded person picks up the lefthanded scissors and deems them weird and uncomfortable. Which they are .. for the right hand of a right-handed person.
What I disagree with is the idea that you can know, just by picking up a pair of scissors if they are left or right-handed. Except for ergonomically shaped ones!, you can't immediately tell. It's only obvious that something is wrong when you try to use them, and even then, I don't think many people would know why.
So it's not about taste or preference, left handed people learn how to use right-handed scissors, but they can also use left handed scissors in a way that a right-handed person would struggle to.
All that said, the analogy still works because most people don't understand why it doesn't work.