they can generate proteins that bind to specific structures with high accuracy, achieving true cell-specificity and avoiding unwanted pleiotropic effects involves many more variables beyond just protein-protein interactions. These tools are more about expanding our ability to target previously "undruggable" proteins rather than solving the cell-specificity problem outright. however they could be valuable components in developing more targeted therapies when combined with comprehensive research on pleiotropic effects across multiple omics levels. real breakthrough will come from integrating these protein design capabilities with a deeper understanding of complex biological systems and developing strategies for precise delivery and regulation of these novel proteins in vivo.