I think there's an argument for base 16 over 12. It's very slightly worse than base 12 for purely human use, since it's only divisible into halves, quarters and eighths. However, each hex digit maps to an exact number of binary digits, which I think outweighs the benefit of thirds and sixths in a digital world.

Of course, it's all theoretical, because there's no chance this would ever happen short of an apocalypse that takes us back to the stone age, and unless the radiation gives us 12 or 16 fingers, we'd probably just reinvent decimal.