I don't think it's entirely incomparable. You can't control the other drivers on the road either.

Also, you can control your own dose. I've never heard of anyone encountering any long term side effects from trying a single low dose of psilocybin. Especially since some studies show that very low doses aren't any different than placebo.

Then again most people don't start with a very low dose and ramp up slowly because people are human and do dumb things.