There's a good documentary about the John Hopkins research on treating drug resistant depression with psilocybin which unfortunately isn't available any more via the BBC: https://www.bbc.co.uk/programmes/m000w7bq

From my limited personal experience and having attended various psychedelic talks and integration workshops etc., set, setting and (post) support are all really key to help turn what can be a potentially life changing/affirming/challenging event into a beneficial one.

Exactly what I was thinking about! There are some nice studies being done in Switzerland with a trip + 7 (I believe) sessions before and after

So, take some mushrooms from a guy, lie down on the couch, and tell him about your mother.