Not really. Two ligands of the same receptor can have very different effects. There are 5ht2a agonists who don’t even cause perceptual effects. Besides, LSD has activities at several other receptors as well, which contributes to its effect.

Extrapolation of biological effect based on the receptor affinity of a ligand is a pretty crude hypotheses.

I am not inventing this, it is what the study itself suggests.

> To determine whether this reflects a common effect of psilocybin that generalizes across datasets and psychedelics, we calculated dimension 1 scores for extant datasets from participants receiving intravenous (i.v.) psilocybin55 and lysergic acid diethylamide (LSD)56. Psychedelic treatment increased dimension 1 in nearly every participant in the psilocybin and LSD datasets (Fig. 2c), suggesting that this is a common effect across psychedelic drugs and individuals.