Thanks for posting this. My doc just prescribed vtama for me a month ago and my psoriasis was gone in less than a week. I didn’t even finish the sample tube he gave me. Far more effective than the steroid topical cream I was using before. I had no idea what vtama was until reading your post.
Yep. The nice thing about VTAMA is that it can be used continuously, unlike steroid creams. And it's unique among current topical meds in that it can provide sustained remission.
It may be that VTAMA reduces TRM cells in the skin, which are the T-cells responsible for relapse. There's is an ongoing clinical trial right now called KNOCKOUT [1] that gives patients a "megadose" of Skyrizi, an IL-23 inhibitor that has, like VTAMA, been shown to reduce TRM cells. The idea is that a single huge dose could effectively cure psoriasis, or at least suppress it for a very long time. The results so far show that 83% of patients achieved complete clearance after six months, which was sustained throughout the trial period. I'm confident it will be a game changer. Here [2] is an interview with the main researcher.
Among new psoriasis drugs, there is also Zoryve, a PDE4 inhibitor (same mechanism as Otezla) as a cream or foam, which has a different mechanism of action.
