Google just fired the Python team, though that of course might also have political reasons. I don't think that Google or anyone else is prepared to use PyScript.
I would not either, given the attitude of Python core towards security and correctness.
This is where I land too. Python is very handy when I need to do something quickly, I expect to modify exactly what I'm doing often, and security and efficiency are not core goals.
But every time I start to write a class in python, it feels like bikeshedding to me.
I would not either, given the attitude of Python core towards security and correctness.