I always have brew available because I inevitably run into issues with Nix packages (primarily managed by home-manager) on a pretty regular basis. Feels like I would be going in the opposite direction by wrapping them in Nix.
It seems to show up mostly in Python-based applications. Recently, I tried adding pyinfra to my system, but it failed to run because of some weird missing dependencies that I could never figure out.
The other big issues are languages. Most compilers and what not will build artifacts linked to the Nix store, which can result in surprising side effects. I tried switching to pyenv using Nix but then I had strange side-effects when trying to use it with poetry. So now I just install all of my language tools using homebrew and have had zero issues since.
