I'm sure there will be many comments here discussing how awful the side effects are, but from what I can see they're almost all primarily associated with rapid weight loss in general - muscle mass reduction and whatnot seem inevitable when someone drops 100+ lbs of total body weight.
The dual action tirzepatide and the next generation retatrutide that has shown massive ability to reduce the long-term harm from obesity: https://www.vcuhealth.org/news/retatrutide-wiped-out-fat-in-...
I'm sure there will be many comments here discussing how awful the side effects are, but from what I can see they're almost all primarily associated with rapid weight loss in general - muscle mass reduction and whatnot seem inevitable when someone drops 100+ lbs of total body weight.