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>Take the age of the universe, multiple by the rate of expansion to get the total size of the universe, then multiple by the average density of galaxies in the observable universe

My understanding is that, at the largest scales, clusters of galaxies are organized along a series of gravitationally bound filaments, sometimes called the cosmic web.

So they aren't distributed like random noise, but more like a web. I have no reason to think this changes anything about calculating average densities, but it is notable that there's the general density but probably a significantly different density within that structure.



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