The Middle East was at war when the Assyrian Empire conquered its neighbors in the 14th century BC. The Middle East was at war when the Achaemenid Empire conquered its neighbors in the 5th century BC. The Middle East was at war when Jewish tribes rebelled against the Roman Empire in the 1st century AD. The Middle East was at war when the Umayyad Caliphate expanded in the 8th century AD. The Middle East was at war when the Ottomans captured Turkey in the 15th century AD. And so on. Some of those groups managed to commit horrific genocides despite having only primitive weapons. This is all terrible but nothing has really changed and unfortunately there is no realistic prospect of breaking the cycle of violence.

As for outside invasions, the same thing has happened to almost every area of the world. Often multiple times. The Middle East is hardly unique in that regard.