Pharo would be the practical one, Squeak the less industrial one. Lots of stuff has been implemented with both, enough that you could run a consultancy and build applications for people.

You'd need to be a bit of a Smalltalk nerd though, and be prepared to do most of the work yourself since there aren't that many smalltalkers to recruit from. You'd also be in competition for developers with companies building software for insurance or ERP, and many smalltalkers spent relatively much time in academia so that could affect salary expectations.