I'm good with letting tiling be a concern of my DE/WM. That's consistent across all the windows I use - I don't have to memorize how tiling works in tmux vs in emacs vs in everything else; I have one setup, I create windows to tile and use tabs to multiplex within tiles. The advantage is that this setup gives me consistent, spacial access to even apps that otherwise won't tile, like Safari or Firefox. All the other advantages of tmux, i.e. that it is programmable etc. are just as true of my WM - I interact with it mostly using scripts I've written, and since this is a local machine I don't care about persistence.