It 2020 being a warm body was enough to get you a job. But in this market there will be a dozen people with directly applicable experience applying as well, those people will get the first calls back.
I've definitely never seen a company prefer a candidate with zero experience in their stack over someone with experience. Slack is given to juniors and people who are adjacent to the desired stack plus have other desired skills, but if you apply to a completely alien stack, i can see your search taking a very long term. I think the only exception I've seen to this is a company that was doing microservices before it was a particularly common skill, so they'd take anyone who could prove they understood the concepts. Even still, most people they hired had an overlap with the desired stack. I just can't see a company with a common stack and a common architecture prefer to hire candidates outside of that stack.
It's best to have 1 stack you have deep expertise of.