Sure, I guess. Just act like all of those vision impaired folks don't exist, and put the entire website in JS that their screen reader can’t handle. Nice.
Disabling JS doesn’t magically make your site screen reader friendly. It’s entirely possible to create a shit layout that uses no JS and is just as horrible to use as a shit layout with JS. Likewise, adding JS doesn’t magically make your site non-screen reader friendly.
What actually makes a site screen reader friendly? Developers that actually write accessibility tests, tab through their site manually, open it with a blindfold and a screen reader to make sure they can navigate it, etc. This myth that no JS automagically enables accessibility needs to die.
