No, not run scremaing! God Emperor and beyond are awesome. But they're not the same thing, no. They're far more philosophical, and kind of about something else.
I think the second and the third was okay, but the fourth was... hmm maybe "decline" is not the right word, it was as if I walked into my favorite coffee shop and they decided to drop a bunch of bricks and PVC pipes on my laps because that's what they do now. (Can't talk about later books - I kinda stopped there and never picked up again. Maybe I should.)
God Emperor is a slog, but sets the groundwork for Heretics and Chapterhouse, and they're in my opinion very good. I've re-read Chapterhouse more than any of the others.
But I think he meant for there to be a final one to follow it, and so it closes off somewhat unsatisfactorily.