I'm in the same boat as you. I regularily switch between high and low keyboards, high and low profile mice, different keyboards/mice at work/home and in addition I switch between right and left handed mouse whenever I feel like it, sometimes even several times an hour. At one point I had two mice at on my desk and grabbed the one which hand was free at the moment. Never had RSI in my 30+ years of active computing though this doesn't prove anything, maybe I'm just lucky. But still, I find it quite liberating to not depend on your must-have setup.

I've reached the point where I can basically work with everything thrown at me. I have preferences, yes, but I'm not the type of person who has to have perfect setup or else nothing gets done.