I don't have a colon (but I do still have a functioning anus). The effects from orlistat are very similar to what I experience 24/7. If you're under 30 or so, eventually your sphincter gets much, much stronger and the excess oil stops affecting you nearly as much. You can hold it in indefinitely until your normal "need to go" timing. This takes about a year or so to train, and you'll have quite a few accidents in the meantime.

I still can't eat too much salmon in one sitting though :-( I don't get diarrhea but I do get stuck on the toilet for ages after.

I remember grabbing a pamphlet when it was new and reading their recommendation to wear dark colored pants and bring a change of clothes to work.

Jesus Christ on a bike, that’s beyond dystopian, that’s completely f—-ked up.

Does the fda allow that?

There’s huge tradeoffs people rarely talk about in Medicine. Significant risk of soiling yourself vs a statistically significant reduction in risk of early death isn’t a big deal for the FDA.

In many cases the hell that is chemo is considered acceptable for even moderate increases in expected lifespan. That’s why people started talking healthy life expectancy vs just life expectancy.

Well duh, if you discuss the side effects with patients, they won't take the drug and the drug people won't send you hookers.

Bizarrely enough, the pressure doesn't always go in that direction.

Yes, why would the FDA restrict what color pants you wear?